Updated October 2, 2026

How long can Ozempic, Wegovy, Mounjaro and Zepbound stay out of the fridge?

Before the first injection, every GLP-1 pen label says fridge, 2–8°C (36–46°F). After that the allowances differ a lot. An opened Ozempic pen gets 56 days at up to 30°C (86°F). Mounjaro and Zepbound single-dose pens get 21 days in total out of the fridge. Trulicity gets 14. None of them may be frozen.

What each label allows

Straight from the US prescribing information for each medicine. “Room temperature” on these labels tops out at 30°C (86°F).

Medicine	Before first use	After first use
Ozempic pen	Fridge, 2–8°C (36–46°F). The label gives no room-temperature allowance before the first injection.	56 days at 15–30°C (59–86°F) or in the fridge
Ozempic single-dose syringe	Fridge. If needed, up to 28 days at 8–30°C (46–86°F).	Single use
Wegovy single-dose pen	Fridge. If needed, before the cap comes off, up to 28 days at 8–30°C (46–86°F).	Single use
Wegovy FlexTouch pen	Fridge, 2–8°C.	56 days at 15–30°C (59–86°F) or in the fridge. The pen's instructions say 20–25°C (68–77°F).
Mounjaro or Zepbound single-dose pen or vial	Fridge. If needed, unrefrigerated up to 30°C (86°F) for a total of 21 days.	Single use
Mounjaro or Zepbound KwikPen or multi-dose vial	Fridge. At room temperature (up to 30°C), throw away after 30 days.	Throw away after 30 days at room temperature, 30 days after first use, or after 4 weekly doses
Saxenda	Fridge, 2–8°C.	30 days at 15–30°C (59–86°F) or in the fridge
Victoza	Fridge, 2–8°C. Left out by mistake: use or throw away within 30 days.	30 days at 15–30°C (59–86°F) or in the fridge
Trulicity	Fridge. If needed, each pen can be kept at room temperature, up to 30°C (86°F), for a total of 14 days.	Single use
Rybelsus (tablet)	No fridge. Store at 20–25°C (68–77°F); 15–30°C is allowed for short spells.	—

Wegovy's own paperwork disagrees with itself: the prescribing information allows 15–30°C for a FlexTouch pen in use, and the pen's instructions say 20–25°C. When two parts of a label disagree, the stricter number is the one to plan a trip around.

The days are a total, not a per-trip allowance

The Mounjaro, Zepbound and Trulicity labels all say “a total of” 21 or 14 days. A pen that spent a week in a bag on holiday and went back in the fridge has used a week of its allowance. Writing the date on the box the first time a pen leaves the fridge is the easy way to keep count.

What every label agrees on

Never frozen. “Do not freeze” and “do not use if it has been frozen” appear on every one of these labels. It is the one rule with no exceptions.
Not next to the cooling element. Ozempic's label says not to store it “directly adjacent to the refrigerator cooling element.” Hotel mini-fridges are small, and the back wall is often the cooling plate, which is how pens end up frozen on a trip.
Out of heat and light. Every label says to protect the pen from heat and light, and the tirzepatide labels add “store in the original carton.”
Over 86°F means trouble. Wegovy's label says to throw the pen away if it was exposed to temperatures above 86°F (30°C), and Victoza's Medication Guide says the same. A car parked in the sun, a beach bag or a hotel room with the air conditioning off can all pass that.

If a pen got too warm or froze

Frozen is simple: every label says not to use it. For heat, Wegovy and Victoza say throw it away. The other labels give no rule for a pen that went over 86°F, so call the pharmacist that filled it before you inject. They can tell you whether your plan covers a replacement.

When you need cold, not just “not hot”

An opened pen within its days needs only to stay under 30°C. Unopened pens are different: on most of these labels they belong at 2–8°C until first use. That matters when you travel with a month of supplies, or anywhere the room temperature runs above 86°F. Our guide to keeping pens cold without a fridge compares the options, and flying with GLP-1 pens covers the TSA rules.

Sources

This guide quotes manufacturer labels and government pages, linked above. Labels change, so the leaflet in your box and your pharmacist have the final word. VialCool sells an empty cooler, not medication.

Something out of date? Email support@vialcool.com.